For superficial, deep cornea ulcers and/or infections in small animals;
150~300microns, in anterior superficial lamellar keratoplasty for non-penetrating cases;
350~400microns, in posterior deep lamellar keratoplasty for Descemetocele cases;
450-500microns, in penetrating cases.
Storage and Transportation:
Room temperature, in refrigerator (2-8 degrees Celsius)is better.
Shelf Life: 18 months.
One unit per one box.
PetsEyes BioCorneaVet is a kind of Decellularized Porcine Corneal Xenografts, specifically developed and designed in the use of veterinary ophthalmology. This graft preserves the complex features that are essential to corneal function, including light transparency, resistance to ultraviolet light, insensitivity to photons and good tensile strength. And the decellularized methods used in the preparation of the graft maximize the elimination of cellular components and nuclear materials, while preserving the extracellular matrix(ECM) proteins and mechanical properties. The porous scaffold structure is an ideal platform for the ingrowth of nerve and vessels as well as the repopulation of host cells like keratocytes and epithelial cells.
This graft is indicated for the treatment of corneal diseases, ulcerations, descemetocele, perforations, feline corneal sequestrum, and trauma where pharmaceutical interventions and/or temporary ocular bandage coverage have failed or are of no use. But the professional veterinary ophthalmologists are the final decision-maker in using this graft or other methods to repair the corneal defects.
In order to successfully use this graft in veterinary ophthalmology, there are a handful of key points needed to be paid attentions.
a. The rehydration time shall be strictly limited within 10-20 seconds, no longer than 60 seconds. And avoid frequent flushing during the suture to prevent the graft from the over-edema.
b. Gently suture the graft and avoid any extra stretch of the stitches on the graft. Intermittent suturings are preferred.
c. The post-op use of contact lens is recommended to promote the completion of re-epithelialization. The eye drops of anti-microorganisms and artificial tears or similars are recommended before and after the keratoplasty.
d. The re-epithelialization time shall be 3-10 days, no longer than 14 days and should be closely observed that is the most key factor for the survival of the graft after the transplantation. The unfulfilled re-epithelialization is the major reason for the dissolution of all grafts and the failure of the keratoplasty.
The major reasons for the unfulfilled re-epithelialization includes reinfections, the incompliance of eye drops, rejection and deficiency of limbus stem cells.
The graft may be seen as thinning or penetrating in the first 14 days, but it is still there and just wait the bio-integration of the graft to be fully completed after 14 days.
The first 14 days after the keratoplasty is very crucial for the final success of the transplantation.
e. The full healing duration for lamellar keratoplasty is approximately 4-8 weeks, and 12-14 weeks for deep lamellar or penetrating keratoplasty.
f. The graft would be gradually a portion of the recipient’s cornea and gradually restore its original thickness with the recession of the newly developed hyper-vascular tissues that commonly occurred from the 4th week post-operatively.
g. The fully restoration of the recipient’s corneal transparency would be achieved for lamellar keratoplasty like most feline sequestrum and those with descemetocele that is the most significant value for this graft, while the preservation of the recipient’s eyeball would be realized for those who are suffered from fully penetration injuries and administered penetrating keratoplasty.
1. Lavaud A, Kowalska ME, Voelter K, Pot SA, Rampazzo A. Penetrating Keratoplasty in Dogs using Acellular Porcine Corneal Stroma (BioCorneaVetTM): A prospective pilot study of five cases. Vet Ophthalmol. 2021;00:1–11. https:// doi.org/10.1111/vop.12884
2. Santillo D, Mathieson I, Corsi F, Göllner R, Guandalini A. The use of acellular porcine corneal stroma xenograft (BioCorneaVetTM) for the treatment of deep stromal and full thickness corneal defects: A retrospective study of 40 cases (2019–2021). Vet Ophthalmol. 2021;00:1–15. https://doi.org/10.1111/vop.12927
3. Xu, H.; Sapienza, J.S.; Jin, Y.; Lin, J.; Zheng, X.; Dong, H.; Diao, H.; Zhao, Y.; Gao, J.; Tang, J.; et al. Lamellar Keratoplasty Using Acellular Bioengineering Cornea (BioCorneaVetTM) for the Treatment of Feline Corneal Sequestrum: A Retrospective Study of 62 Eyes (2018–2021). Animals 2022, 12, 1016. https://doi.org/10.3390/ani12081016